ΕΡΕΥΝΗΤΙΚΟ ΕΡΓΟ ΤΗΣ
Γ’ ΠΑΝΕΠΙΣΤΗΜΙΑΚΗΣ ΠΑΘΟΛΟΓΙΚΗΣ ΚΛΙΝΙΚΗΣ
ΣΧΕΤΙΖΟΜΕΝΟ ΜΕ ΤΗΝ ΠΑΝΔΗΜΙΑ COVID-19

 

Η πανδημία COVID-19 υπήρξε παγκόσμια ένα συνταρακτικό γεγονός. Η κοινωνική αποστασιοποίηση, η αυστηρή τήρηση και χρήση των μέτρων ατομικής προστασίας, καθώς και η ανακάλυψη και διερεύνηση μιας νέας νόσου αποτελούν στοιχεία που σηματοδοτούν την ιστορικότητα των προηγούμενων μηνών. Κατά την περίοδο της πανδημίας, η επιστημονική κοινότητα είναι ο μοναδικός φορέας ο οποίος μπορεί να παρέχει αξιόπιστες πληροφορίες και ασφαλή συμπεράσματα, σχετικά με ζητήματα που αφορούν τη νέα νόσο.
Το Νοσοκομείο Σωτηρία αποτέλεσε και αποτελεί επίκεντρο των εξελίξεων κατά τη διάρκεια της πανδημίας. H Γ’ Πανεπιστημιακή Παθολογική Κλινική συμμετείχε ενεργά στη συνολική προσπάθεια με την ίδρυση και ανελλιπή λειτουργία Κλινικής COVID19, συνεχίζοντας παράλληλα και την κανονική λειτουργία της. Οι εργαζόμενοι της Κλινικής συνέλεξαν σημαντική εμπειρία και γνώση, σχετικά με ζητήματα που αφορούν τη νέα αυτή νόσο.
Η αποτύπωση αυτής της εμπειρίας και γνώσης αποτελεί σημαντικό σταθμό στην εκπαιδευτική και ερευνητική μας πορεία. Απευθύνεται στη διεθνή επιστημονική κοινότητα παρέχοντας πολύτιμες και τεκμηριωμένες επιστημονικές πληροφορίες, στοχεύοντας στην παροχή των βέλτιστων θεραπευτικών υπηρεσιών στους ασθενείς μας.

Ο Διευθυντής της Κλινικής

 

Κωνσταντίνος Ν Συρίγος, MD, PhD, FCCP
Καθηγητής

 

 

ΣΥΝΟΠΤΙΚΗ ΠΑΡΟΥΣΙΑΣΗ ΤΩΝ ΔΙΕΘΝΩΝ ΔΗΜΟΣΙΕΥΣΕΩΝ

 

ΔΕΚΕΜΒΡΙΟΣ 2020 Anticoagulation therapy in COVID-19: Is there a dose-dependent benefit?

Kollias A, Kyriakoulis KG, Syrigos NK, Stergiou GS. Anticoagulation therapy in COVID-19: Is there a dose-dependent benefit? Thromb Res. 2020 Dec 29;199:19-20. doi: 10.1016/j.thromres.2020.12.013. Epub ahead of print. PMID: 33385796; PMCID: PMC7771905.

 

Beneficial Effects of Intermediate Dosage of Anticoagulation Treatment on the Prognosis of Hospitalized COVID-19 Patients: The ETHRA Study

Poulakou G, Dimakakos E, Kollias A, Kyriakoulis KG, Rapti V, Trontzas I, Thanos C, Abdelrasoul M, Vantana T, Leontis K, Kakalou E, Argyraki K, Baraboutis I, Michelakis E, Giamarellos-Bourboulis E, Dimakou K, Tsoukalas G, Rapti A, Michelakis ED, Syrigos KN. Beneficial Effects of Intermediate Dosage of Anticoagulation Treatment on the Prognosis of Hospitalized COVID-19 Patients: The ETHRA Study. In Vivo. 2021 Jan-Feb;35(1):653-661. doi: 10.21873/invivo.12305. PMID: 33402523.

 

Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19

Psichogiou M, Karabinis A, Pavlopoulou ID, Basoulis D, Petsios K, Roussos S, Pratikaki M, Jahaj E, Protopapas K, Leontis K, Rapti V, Kotanidou A, Antoniadou A, Poulakou G, Paraskevis D, Sypsa V, Hatzakis A. Antibodies against SARS-CoV-2 among health care workers in a country with low burden of COVID-19. PLoS One. 2020 Dec 3;15(12):e0243025. doi: 10.1371/journal.pone.0243025. PMID: 33270691.

 
ΝΟΕΜΒΡΙΟΣ 2020

 

Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization

Kollias A, Kyriakoulis KG, Syrigos K. Comment on: Tartof SY, Qian L, Hong V, Wei R, Nadjafi RF, Fischer H, Li Z, Shaw SF, Caparosa SL, Nau CL, Saxena T, Rieg GK, Ackerson BK, Sharp AL, Skarbinski J, Naik TK, Murali SB. Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization. Ann Intern Med. 2020 Nov 17;173(10):773-781. doi: 10.7326/M20-3742. Epub 2020 Aug 12. PMID: 32783686; PMCID: PMC7429998.

 

Anti-SARS-CoV-2 Antibody Responses in Convalescent Plasma Donors Are Increased in Hospitalized Patients; Subanalyses of a Phase 2 Clinical Study

Terpos E, Politou M, Sergentanis TN, Mentis A, Rosati M, Stellas D, Bear J, Hu X, Felber BK, Pappa V, Pagoni M, Grouzi E, Labropoulou S, Charitaki I, Ntanasis-Stathopoulos I, Moschandreou D, Bouhla A, Saridakis S, Korompoki E, Giatra C, Bagratuni T, Pefanis A, Papageorgiou S, Spyridonidis A, Antoniadou A, Kotanidou A, Syrigos K, Stamoulis K, Panayiotakopoulos G, Tsiodras S, Alexopoulos L, Dimopoulos MA, Pavlakis GN. Anti-SARS-CoV-2 Antibody Responses in Convalescent Plasma Donors Are Increased in Hospitalized Patients; Subanalyses of a Phase 2 Clinical Study. Microorganisms. 2020 Nov 28;8(12):E1885. doi: 10.3390/microorganisms8121885. PMID: 33260775.

   
ΟΚΤΩΒΡΙΟΣ 2020 Update in COVID-19 in the intensive care unit from the 2020 HELLENIC Athens International symposium

Rello J, Belliato M, Dimopoulos MA, Giamarellos-Bourboulis EJ, Jaksic V, Martin-Loeches I, Mporas I, Pelosi P, Poulakou G, Pournaras S, Tamae-Kakazu M, Timsit JF, Waterer G, Tejada S, Dimopoulos G. Update in COVID-19 in the intensive care unit from the 2020 HELLENIC Athens International symposium. Anaesth Crit Care Pain Med. 2020 Oct 22:S2352-5568(20)30240-X. doi: 10.1016/j.accpm.2020.10.008. Epub ahead of print. PMID: 33172592; PMCID: PMC7580531.

 

ICM Editorial Board. Ensuring editorial continuity and quality of science during the COVID-19 storm: the ICM experience.

Bein T, Vargiolu A; ICM Editorial Board. Ensuring editorial continuity and quality of science during the COVID-19 storm: the ICM experience. Intensive Care Med. 2020 Oct;46(10):1918-1920. doi: 10.1007/s00134-020-06207-y. PMID: 32815029; PMCID: PMC7437641.

 

Patients with Inflammatory Bowel Disease Are Not at Increased Risk of COVID-19: A Large Multinational Cohort Study

Allocca M, Chaparro M, Gonzalez HA, Bosca-Watts MM, Palmela C, D’Amico F, Zacharopoulou E, Kopylov U, Ellul P, Bamias G, Ntelis V, Lahat A, Mantzaris GJ, Papaconstantinou I, Katsanos K, Uspenskaya Y, Christodoulou D, Ben Horin S, Peyrin-Biroulet L, Torres J, Sebastian S, Gisbert JP, Danese S, Fiorino G. Patients with Inflammatory Bowel Disease Are Not at Increased Risk of COVID-19: A Large Multinational Cohort Study. J Clin Med. 2020 Oct 31;9(11):3533. doi: 10.3390/jcm9113533. PMID: 33142843; PMCID: PMC7693947.

 

Anakinra To Prevent Respiratory Failure In COVID-19

Kyriazopoulou E, Panagopoulos P, Metallidis S, Dalekos GN, Poulakou G, Gatselis N, Karakike E, Saridaki M, Loli G, Stefos A, Prasianaki D, Georgiadou S, Tsachouridou O, Petrakis V, Tsiakos K, Kosmidou M, Lygoura V, Dareioti M, Milionis H, Papanikolaou IC, Akinosoglou K, Myrodia D-M, Gravvani A, Stamou A, Gkavogianni T, Katrini K, Marantos T, Trontzas IP, Syrigos K, Chatzis L, Chatzis S, Vechlidis N, Avgoustou C, Chalvatzis S, Kyprianou M, van der Meer JWM, Eugen-Olsen J, Netea MG, Giamarellos-Bourboulis EJ. medRxiv 2020.10.28.20217455; doi: https://doi.org/10.1101/2020.10.28.20217455.

   
ΣΕΠΤΕΜΒΡΙΟΣ 2020 Venous thromboembolism in the era of COVID-19

Kyriakoulis KG, Kokkinidis DG, Kyprianou IA, Papanastasiou CA, Archontakis-Barakakis P, Doundoulakis I, Bakoyiannis C, Giannakoulas G, Palaiodimos L. Venous thromboembolism in the era of COVID-19. Phlebology. 2020 Sep 10:268355520955083. doi: 10.1177/0268355520955083. Epub ahead of print. PMID: 33249999.

 

Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine

Gerotziafas GT, Catalano M, Colgan MP, Pecsvarady Z, Wautrecht JC, Fazeli B, Olinic DM, Farkas K, Elalamy I, Falanga A, Fareed J, Papageorgiou C, Arellano RS, Agathagelou P, Antic D, Auad L, Banfic L, Bartolomew JR, Benczur B, Bernardo MB, Boccardo F, Cifkova R, Cosmi B, De Marchi S, Dimakakos E, Dimopoulos MA, Dimitrov G, Durand-Zaleski I, Edmonds M, El Nazar EA, Erer D, Esponda OL, Gresele P, Gschwandtner M, Gu Y, Heinzmann M, Hamburg NM, Hamadé A, Jatoi NA, Karahan O, Karetova D, Karplus T, Klein-Weigel P, Kolossvary E, Kozak M, Lefkou E, Lessiani G, Liew A, Marcoccia A, Marshang P, Marakomichelakis G, Matuska J, Moraglia L, Pillon S, Poredos P, Prior M, Salvador DRK, Schlager O, Schernthaner G, Sieron A, Spaak J, Spyropoulos A, Sprynger M, Suput D, Stanek A, Stvrtinova V, Szuba A, Tafur A, Vandreden P, Vardas PE, Vasic D, Vikkula M, Wennberg P, Zhai Z; Scientific Reviewer Committee. Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine. Thromb Haemost. 2020 Sep 13. doi: 10.1055/s-0040-1715798. Epub ahead of print. PMID: 32920811.

   
ΑΥΓΟΥΣΤΟΣ 2020 Cardiac injury and prognosis in COVID-19: Methodological considerations and updated meta-analysis

Kollias A, Kyriakoulis KG, Destounis A, Stergiou GS, Syrigos K. Cardiac injury and prognosis in COVID-19: Methodological considerations and updated meta-analysis. J Infect. 2020 Aug;81(2):e181-e182. doi: 10.1016/j.jinf.2020.06.031. Epub 2020 Jun 18. PMID: 32562792; PMCID: PMC7299868.

 

Heterogeneity in reporting venous thromboembolic phenotypes in COVID-19: methodological issues and clinical implications

Kollias A, Kyriakoulis KG, Stergiou GS, Syrigos K. Heterogeneity in reporting venous thromboembolic phenotypes in COVID-19: methodological issues and clinical implications. Br J Haematol. 2020 Aug;190(4):529-532. doi: 10.1111/bjh.16993. Epub 2020 Jul 26. PMID: 32621757; PMCID: PMC7362074.

   
ΙΟΥΛΙΟΣ   2020 The Greek Response to COVID-19: A True Success Story from an IBD Perspective

Bamias G, Lagou S, Gizis M, Karampekos G, Kyriakoulis KG, Pontas C, Mantzaris GJ. The Greek Response to COVID-19: A True Success Story from an IBD Perspective. Inflamm Bowel Dis. 2020 Jul 17;26(8):1144-1148. doi: 10.1093/ibd/izaa143. PMID: 32476001; PMCID: PMC7313988.

 

COVID-19 and heart injury: Appropriate methodology is crucial for assessing the emerging evidence

Kollias A, Kyriakoulis KG, Stergiou GS. COVID-19 and heart injury: Appropriate methodology is crucial for assessing the emerging evidence. Prog Cardiovasc Dis. 2020 Jul-Aug;63(4):533. doi: 10.1016/j.pcad.2020.06.001. Epub 2020 Jun 3. PMID: 32504623; PMCID: PMC7267796.

 

Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research

Bikdeli B, Madhavan MV, Gupta A, Jimenez D, Burton JR, Der Nigoghossian C, Chuich T, Nouri SN, Dreyfus I, Driggin E, Sethi S, Sehgal K, Chatterjee S, Ageno W, Madjid M, Guo Y, Tang LV, Hu Y, Bertoletti L, Giri J, Cushman M, Quéré I, Dimakakos EP, Gibson CM, Lippi G, Favaloro EJ, Fareed J, Tafur AJ, Francese DP, Batra J, Falanga A, Clerkin KJ, Uriel N, Kirtane A, McLintock C, Hunt BJ, Spyropoulos AC, Barnes GD, Eikelboom JW, Weinberg I, Schulman S, Carrier M, Piazza G, Beckman JA, Leon MB, Stone GW, Rosenkranz S, Goldhaber SZ, Parikh SA, Monreal M, Krumholz HM, Konstantinides SV, Weitz JI, Lip GYH; Global COVID-19 Thrombosis Collaborative Group. Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research. Thromb Haemost. 2020 Jul;120(7):1004-1024. doi: 10.1055/s-0040-1713152. Epub 2020 May 30. PMID: 32473596; PMCID: PMC7516364.

   
ΙΟΥΝΙΟΣ 2020 Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action

Kollias A, Kyriakoulis KG, Dimakakos E, Poulakou G, Stergiou GS, Syrigos K. Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action. Br J Haematol. 2020 Jun;189(5):846-847. doi: 10.1111/bjh.16727. Epub 2020 May 4. PMID: 32304577; PMCID: PMC7264537.

 

Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease

Deftereos SG, Giannopoulos G, Vrachatis DA, Siasos GD, Giotaki SG, Gargalianos P, Metallidis S, Sianos G, Baltagiannis S, Panagopoulos P, Dolianitis K, Randou E, Syrigos K, Kotanidou A, Koulouris NG, Milionis H, Sipsas N, Gogos C, Tsoukalas G, Olympios CD, Tsagalou E, Migdalis I, Gerakari S, Angelidis C, Alexopoulos D, Davlouros P, Hahalis G, Kanonidis I, Katritsis D, Kolettis T, Manolis AS, Michalis L, Naka KK, Pyrgakis VN, Toutouzas KP, Triposkiadis F, Tsioufis K, Vavouranakis E, Martinèz-Dolz L, Reimers B, Stefanini GG, Cleman M, Goudevenos J, Tsiodras S, Tousoulis D, Iliodromitis E, Mehran R, Dangas G, Stefanadis C; GRECCO-19 investigators. Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial. JAMA Netw Open. 2020 Jun 1;3(6):e2013136. doi: 10.1001/jamanetworkopen.2020.13136. PMID: 32579195; PMCID: PMC7315286.

 

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-of-the-Art Review

Bikdeli B, Madhavan MV, Jimenez D, Chuich T, Dreyfus I, Driggin E, Nigoghossian C, Ageno W, Madjid M, Guo Y, Tang LV, Hu Y, Giri J, Cushman M, Quéré I, Dimakakos EP, Gibson CM, Lippi G, Favaloro EJ, Fareed J, Caprini JA, Tafur AJ, Burton JR, Francese DP, Wang EY, Falanga A, McLintock C, Hunt BJ, Spyropoulos AC, Barnes GD, Eikelboom JW, Weinberg I, Schulman S, Carrier M, Piazza G, Beckman JA, Steg PG, Stone GW, Rosenkranz S, Goldhaber SZ, Parikh SA, Monreal M, Krumholz HM, Konstantinides SV, Weitz JI, Lip GYH; Global COVID-19 Thrombosis Collaborative Group, Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working Group on Pulmonary Circulation and Right Ventricular Function. COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 Jun 16;75(23):2950-2973. doi: 10.1016/j.jacc.2020.04.031. Epub 2020 Apr 17. PMID: 32311448; PMCID: PMC7164881.